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In aging, oligodendrocytes and OPCs also accumulate signs of oxidative DNA (mitochondrial and nuclear) damage, a feature which is commonly found in neurodegenerative diseases like Alzheimers disease and MS (Tse and Herrup, 2017)

TRAF3, a key member of this family, is frequently suppressed in glioblastoma (GBM) due to promoter hypermethylation

Gonsalves N, Doerfler B, Zalewski A, Yang GY, Martin LJ, Zhang X et al

A., & Anagnostou, E

alcohol exposure to environmental toxins (pollution, pesticides, plastics) high or chronic emotional stress circadian rhythm dysregulation (poor sleep) lack of exercise infections lack of antioxidant intake Important note

Its used to address primary and secondary carnitine deficiency, and is also associated with supporting angina management, alongside broader use in wellness and metabolic support