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Description

Positron emission tomography (PET) has poor results in distinguishing melanoma from nevi

For melanocortin receptor pharmacology and MC4R pathway research, Melanotan-2 provides a valuable nonselective tool

Though afamelanotide is similar to melanotan, the FDA has not approved it for use as a self-tanner

The mechanism is straightforward: MC1R activation on melanocytes upregulates tyrosinase activity, driving conversion of tyrosine to eumelanin (the dark, photoprotective form of melanin)