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Collectively, these mitochondria-targeted therapeutic strategiesranging from direct antioxidant approaches and metabolic modulation to quality control enhancement and mitochondrial transferaddress distinct but interconnected aspects of mitochondrial dysfunction in diabetic wounds (Table 2)

Harvey CJ, Thimmulappa RK, Sethi S, et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Levine A., Koletzko S., Turner D., Escher J.C., Cucchiara S., de Ridder L., Kolho K.-L., Veres G., Russell R.K., Paerregaard A., et al

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In such cases, the excessive production of ROS by leukocytes surpasses the capacity of the semens antioxidant defenses, leading to pronounced oxidative stress