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Figure 2 2.1.1 Effects on innate immune system Neutrophils are the most abundant leukocytes population in peripheral blood, and they exert their activity early during inflammation, releasing cytokines, proteases, producing reactive oxygen species (ROS), and creating neutrophils extracellular traps (NETs) (33) Neutrophils represent the main targets of A1AT action: being an anti-protease, its primary effect is to inhibit serine proteases deriving from degranulating neutrophils including NE, cathepsin G and PR3 (34)

PCA was performed in R (version 3.6.3) to visualize the clustering of the gene expression data using log-fold transcript abundance of gene arrays in each group

Dysbiotic microbiome-metabolome axis in childhood obesity and metabolic syndrome

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