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856 Multiple studies have demonstrated that ferroptosis occurs in damaged synovial areas in OA patients, who have higher lipid peroxidation levels than healthy individuals

They facilitate the translocation of nuclear factor-like 2 (Nrf2) to the nucleus by modifying its binding partner kelch-like ECH-associated protein 1 (Keap1) 23

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This seemingly simple structural change produces approximately a 10-fold increase in potency compared to full-length IGF-1 in stimulating anabolic processes including protein synthesis, muscle hypertrophy, and cellular proliferation