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Type of EDS: Hypermobile EDS (hEDS) Distinguishing Features: Generalized joint hypermobility Joint instability Chronic pain Type of EDS: Classical EDS (cEDS) Distinguishing Features: Skin fragility with extensive atrophic scarring Very stretchy skin with a velvety or doughy texture Type of EDS: Vascular EDS (vEDS) Distinguishing Features: Arterial fragility with aneurysm/dissection/rupture Organ fragility and rupture Extensive bruising Pneumothorax (collapsed lung) Type of EDS: Periodontal EDS (pEDS) Distinguishing Features: Severe, early-onset gum disease with tooth loss Pretibial plaques (discoloration of shins) Type of EDS: Kyphoscoliotic EDS (kEDS) Distinguishing Features: Congenital/early-onset kyphoscoliosis Congenital hypotonia (low muscle tone) Type of EDS: Spondylodysplastic EDS (spEDS) Distinguishing Features: Short stature Muscle weakness Limb bowing Craniofacial features Type of EDS: Brittle cornea syndrome (BCS) Distinguishing Features: Severe problems with the cornea of the eye Hearing loss Type of EDS: Arthrochalasia EDS (aEDS) Distinguishing Features: Severe joint hypermobility Congenital bilateral hip dislocation Type of EDS: Musculocontractural EDS (mcEDS) Distinguishing Features: Congenital multiple contractures Craniofacial features Type of EDS: Classical-like EDS (clEDS) Distinguishing Features: Stretchy, velvety skin without atrophic scarring Foot deformities Leg swelling Type of EDS: Dermatosparaxis EDS (dEDS) Distinguishing Features: Severe skin fragility Craniofacial features Loose, excess skin Severe bruising Short limbs Type of EDS: Myopathic EDS (mEDS) Distinguishing Features: Congenital hypotonia (low muscle tone at birth) Proximal joint contractures Type of EDS: Cardiac-valvular EDS (cvEDS) Distinguishing Features: Severe heart valve insufficiency How is joint hypermobility assessed

Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
Modifier -25 becomes relevant when a problem-oriented E/M is also performed on the same day for instance, the child is seen for the scheduled immunization, and during the visit the provider also separately evaluates and manages an acute complaint like an ear infection
Initially, the finger is painful and swollen around the PIP joint
B-12 also boosts energy levels, which can help to improve overall mental health