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A 2013 study by Teekachunhatean et al., published in ISRN Pharmacology , found that caffeine from coffee enemas is absorbed at comparable levels to oral coffee consumption, which is relevant for those sensitive to caffeine

2020 [cited 2025 Apr 25];9:209

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1,3,6 Dietary Sources of the Longevity Vitamin Ergothioneine Cognitive decline and neuroprotection Several studies have reported that lower blood concentrations of EGT are consistently associated with a higher prevalence of cognitive impairment and an accelerated rate of cognitive decline in older adults

10.1016/j.apsb.2021.07.013 Acta Pharm

Research on semorelin is limited, but benefits may include better muscle tone and strength, reduced body fat, as well as improved energy and cognition