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Kitajima S, Morimoto M, Sagara E et al (2001) Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice

Extreme purging, even if it would eventually resolve, may not be acceptable depending on your circumstances

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Vaccine efficacy studies determine how protective vaccine regimens are in a given cohort using defined end points , e.g., efficacy against symptomatic infection or against admission to intensive care