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When these microbes migrate into the small intestine, they can begin fermenting food, leading to SIBO (small intestinal bacterial overgrowth)

Interestingly, lactylation of NUSAP1 at lysine 34 prevents its protein degradation and increases its expression in PDAC cells, establishing an NUSAP1-LDHA-glycolysis-lactate loop that promotes PDAC metastasis

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( Figure 2A ) (Tonkin et al., 2013

Overall, these mechanisms stunt cell proliferation, alter metabolism and gene expression patterns and induce high levels of ROS production, maintaining the cellular senescent phenotype