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This murine model was also used in a transcriptomic study of oral melatonin which found that melatonin alleviated lung damage and inflammation and reduced necroptosis [76]

This neuroprotective mechanism was found to occur in concert with a suppression of proinflammatory cytokines released from the activated microglia, suggesting an anti-inflammatory mechanism upstream from the neurodegeneration of dopaminergic neurons

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doi: 10.1016/j.freeradbiomed.2024.11.021 42 EltokhyAKEl-ShaerRAAEl-DeebOSFarghalEEIbrahimRRElesawyRet al

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