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Plusieurs tudes observationnelles ont associ un taux srique lev de B12 : un risque accru de certains cancers chez les fumeurs (notamment du poumon)

[] Heavy metals, mainly lead, may also substitute bivalent cations such as calcium ion (Ca2+), magnesium ion (Mg2+), iron (II) (Fe 2 +) and monovalent cations such as sodium ion (Na+) and cause dysfunctions where these cations act as cofactors in various enzyme activities