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These residues form hydrophobic interactions with the methyl groups, while the carbonyl O of P124 hydrogen bonds with the nitrogen atom, which conforms to a tetrahedral configuration suggesting that it is protonated

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TgCBS is also strongly implicated in the production of H 2 S, being highly efficient in catalyzing the -replacement of l-Cys with l-Hcys

After exposure the ratio of viable spermatozoa to the total number of sperm in the epididymis was found to have significantly decreased (108)

However, the precise regulatory mechanism of crosstalk between ferroptosis and mitophagy in the context of OA remains unclear