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Inhibiting an endogenous metabolic enzyme can create effects beyond the intended experimental target, particularly when human exposure and long-term safety have not been established

Whether this observation is solely the consequence of translocation of Parasutterella bacteria from the intestine to the EWAT or driven by more indirect mechanisms such as bacterially-produced metabolites 85 is yet to be determined

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Patients received 74 MBq (2 mCi) of the radioligand and underwent PET/CT over the next 8 days with no adverse events reported

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