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Clinical trials show that side effects become less frequent and less intense with continued treatment over 612 months

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Post-infusion CAR T cells in bone marrow (BM) of LTR have high immunometabolic plasticity and mTOR-pS6 expression supported by the BM microenvironment

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Therefore, women with the MTHFR C677T genotype become more affected by rising demands of folate and, in turn, suffer more adverse effects