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UV-irradiation, especially UVA and UVB results in the production of ROS

performed Gpx4 knockout in mouse myeloid immune cell subpopulations, and the development and homeostasis of tissue-resident macrophages in the lung, peritoneum, spleen, and bone marrow (considered as M0 state) were unaffected [95]

This recruitment is orchestrated by chemokines, adhesion molecules, and other signaling molecules released by the inflamed tissue (77).Understanding the complex interplay between immune cell recruitment and oxidative stress in IBD is crucial for developing targeted therapies