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This mitochondria/rAAV-IGF-I system improved proliferation, survival, extracellular-matrix synthesis, and mitochondrial function in transplanted chondrocytes, upregulated SOX9 and the fusion protein Mfn-1, and reduced expression of the fission protein Drp-1 and proinflammatory mediators (Zhong et al., 2025)

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Diese Vernderung hat tiefgreifende Vorteile fr die Behandlung von rheumatoider Arthritis durch Glutathion: Unterdrckung von Zytokinstrmen durch NF-B-Hemmung, Entlastung der TNF-- und IL-6-Modulation [8]