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Su H, Yuan P, Lei H, Zhang L, Deng D, Zhang L, et al

SERCA2b mutation accelerates the depletion of ER Ca 2+ , promotes ERS, and aggravates the stimulation of glutamate to HT22 cells excitotoxicity [114]

Importantly, no serious adverse events were observed, and GH pulse frequency was preserved

Summary and future directions Therapeutic resistance and suboptimal efficacy remain significant challenges in CD management

However, the effect was diminished by Inhibitors of PI3k and Akt, indicating that PI3/Akt pathway is important for cell growth induced by IGF-1 [2]