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5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

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However, these findings are still awaiting further confirmation

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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AOD-9604 does not interact with that pathway