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Symptoms include: fever cough chest pain shortness of breath wheezing fatigue difficulty swallowing bad breath excessive sweating Chronic obstructive pulmonary disease (COPD) Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease caused by alveolar (air sac) and airway damage

9 Endothelial dysfunction characterized by abnormal vascular reactivity and atherogenic cytokines may be present

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Even under androgen deprivation therapy, androgen levels are sufficiently high to activate overexpressed AR, which is due to intratumoral in-situ synthesis 141 and residual synthesis in the adrenal gland 142 , along with decreased levels of the androgen inactivating enzymes CYP3A4, CYP3A5, and CYP3A7 in patient tissue samples 143

Curr Health Sci J 2020;46(2):156-166