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Li Li, MD1,3 Author Affiliations Article Information JAMA Netw Open

Homocysteine is a toxic amino acid and, in the blood, homocysteine causes arterial sclerosis, putting strain on the heart and vascular system

Abdominoperineal resection Abdominoperineal resection is a surgical procedure that involves the removal of the lower end of the large bowel i.e., colon, rectum or anus

Wang H, Storlien LH, Huang X-F

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When looking at studies, you might also find that papers define it in slightly different ways, but generally speaking, this serves as a good starting point