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Contraindications include Leber's disease and certain chemotherapy protocols

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C., & Bare, B

Neurobiology of Aging 13, 1-7CrossRefGoogle ScholarPubMed 155Smith, M.A., Harris, P.L., Sayre, L.M

The altered homeostatic incretin levels in PAR2-G37I or PAR2-R38E versus WT mice were not caused by apparent changes in metabolism, as no significant differences in food and fluid intake, energy expenditure, respiratory exchange ratio, or locomotor activity were observed in indirect calorimetry (Supplemental Figure 2, A and B)

And yet, they miss what a simple test (although not standard) could have revealed- lp(a) is high, fasting insulin is high, HOMA-IR is high - all while they have normal A1c or close to normal LDL