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The addition or deletion of an exon or intron is critical for the diversification of multigene families

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Perez MJ, Britz O (2009) Bile-acid-induced cell injury and protection

Aside from the three FDA-approved clinical indications, PDE5-Is have been intensively investigated for their potential use in the treatment of various emerging indications, such as cancer, central nervous system (CNS) and cardiovascular system (CVS) related diseases, kidney diseases, cystic fibrosis and diabetes, all of which will be discussed herein

The organic layer was evaporated in vacuo, and the residue was redissolved in 0.5 mL of 50% MeOH before injection onto LC column

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