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This pathway yields NADPH, which is essential for converting oxidized glutathione back to its reduced form

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A lack of response by the treated animal, or the development of new signs, may suggest that an overgrowth of nonsusceptible organisms has occurred

Still, some patients may not respond well to the positive effects of glucocorticoids including those who smoke, have certain type of asthma phenotypes, COPD or some interstitial diseases

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While glutathione is generally safe, some individuals may experience mild side effects