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Further in-depth pharmacokinetic studies on humans and toxicology research, the mechanism of combination therapy, and research on new CHE-based biomaterials for reducing drug toxicity and structurally optimized analogs are required to enhance the efficacy and safety of CHE, and more clinical studies are required in the future to validate preclinical studies of CHE as an antitumor strategy

doi: 10.1016/j.brainres.2025.149494 87 KellerCWAdamopoulosIELunemannJD

This method is nearly identical to naming an alcohol and is used by the IUPAC, e.g

JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet al

This unique property may contribute to its diverse effects across multiple tissue types

Since H3K18la can also co-mark enhancers with H3K27ac and H3K4me3, whether H3K18la can enhance STEAP3 remains to be further studied, and other peaks bound by H3K18la can be further explored for potential enhancer activity 26