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After ischemic injury, matrix remodeling and the formation of avascular scar tissue hinder cell engraftment and survival, limiting the effectiveness of cell replacement therapy

Activated macrophages are generally categorized into two kinds: M1 macrophages, which participate in pro-inflammatory responses, and M2 macrophages, which engage in anti-inflammatory responses (84)

Because homocysteine is an excitatory amino acid, it activates metabotropic glutamate receptors (mGluRs) and NMDA receptors, causing increased glutamatergic neurotransmission

For local delivery systems, most current studies rely on static culture or shortterm animal models, which fail to adequately recapitulate the complex physiological conditions characterized by the coexistence of gingival crevicular fluid flow and enzymatic degradation

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Moreover, insulin resistance in obese humans is associated with a unique profile of IgG autoantibodies