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In Study JMCH, incidences of Grade 3-4 neutropenia (38% versus 23%), thrombocytopenia (9% versus 5%), febrile neutropenia (9% versus 0.6%), and neutropenic infection (6% versus 0) were higher in patients who received pemetrexed plus cisplatin without vitamin supplementation as compared to patients who were fully supplemented with folic acid and vitamin B12 prior to and throughout pemetrexed plus cisplatin treatment

Dont stop prescribed supplements without advice

Increased flux of key cellular energy regulators, including NAD + and SAM, may potentially define the therapeutic mechanism-of-action of NNMT inhibitors

Patients who dont have a deficiency but are looking to optimize their B12 levels may utilize weekly or monthly injections depending on their response to treatment

A Vitamin B12 test helps detect deficiencies early and prevents serious health issues

What are the risks or side effects