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Shanti Mulling: correct

46 APAP can freely cross the selective maternal-fetal barrier of the placenta, after which it can then be metabolized by fetal hepatocytes, causing fetal hepatic necrosis if appropriate therapy with NAC is not administered in a timely manner

Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet

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Induction of these genes is known to be highly protective against APAP toxicity [119]

However, ISA was identified as inhibitors of Nur77 and Nurr1, indicating its neuroprotection was not mediated by Nur77 and Nurr1 (Jung et al., 2019