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37 Similarly, breath-actuated jet nebulizers, like the AeroEclipse II BAN (Monaghan Medical Corporation, Plattsburgh, NY), also deliver aerosol only on inspiration and tend to decrease drug wastage during aerosol therapy

Most patients with DOA plus carry missense variants affecting the GTPase domain rather than truncating mutations of OPA1, suggesting that a dominant negative effect might play a role in the pathogenesis of the plus phenotype [91,92,93]

Untreated glaucoma can cause blindness