napqi and glutathione Acetaminophen metabolism NAPQI-mediated mitochondrial effects Fasting depletes Glutathione, turning "safe"
Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. Biopharmaceutics and Drug Disposition Pharmacology Journal Wiley Online Library NAPQI an overview ScienceDirect Topics glutathione napqi Did you know that high doses of paracetamol can be toxic to your liver? Critical care toxicology for acetaminophen overdose
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