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Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis

He also serves on the board of directors of the company

Prevalence and clinical impact of Met Y1253D-activating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx

R 3 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, optionally substituted C 6 -C 10 aryl, optionally substituted C 3 -C 9 heteroaryl, OR 6 , NR 5 R 6 , C(O)R 7 , -0O 2 R 6 , C(O)NR 5 R 6 , N(R 5 )C(O)R 7 , N(R 5 )CO 2 R 7 , NHS(O) 2 R 7 , S(O) 2 NR 5 R 6 , or R 2 and R 3 together form an optionally substituted C 2 -C 7 heterocycloalkyl ring

Heart rate changes Increased heart rate has been noted as a potential side effect of cagrilintide, consistent with observations across the broader class of weight loss medications

Preclinical studies demonstrate biologic activity relevant to tissue repair, supporting biologic plausibility but not clinical effectiveness