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Description

The rate-limiting enzyme of cholesterogenesis, HMG-CoA-reductase, is inhibited noncompetitively by DCA

Ultrathin sections were cut with a diamond knife using a Leica Ultracut S ultra-microtome (Austria), stained with both methanolic uranyl acetate and lead citrate before viewing in a JEOL 1011 transmission electron microscope (Japan) at 60 kV

doi: 10.3389/fcell.2018.00090 Received 31 May 2018 Accepted 25 July 2018 Published 15 August 2018 Volume 6 - 2018 Edited by Concetta Bubici, Brunel University London, United Kingdom Reviewed by Alice Newman, University of Glasgow, United Kingdom