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We also found that the tetranor-PGDM and tetranor-PGEM concentrations were increased in parallel with disease severity, with higher values observed in patients without ambulatory function, such as those with severe and typical FCMD, compared to those with the ambulatory mild FCMD phenotype

By considering such heterogeneity of ROS concentration in the tissues, researchers work on design and synthesis of ROS-responsive materials to target inflammation, cancer cells, and wound sites to manage ROS in pathological regions