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However, given the apparent protective role of GLO-1 under certain conditions, direct targeting of GLO-1 alone may not represent the optimal therapeutic strategy

The highest concentrations of glutathione exist in the liver, where detoxification primarily takes place

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Iron that is not bound to transferrin may target hepatic and other parenchymatous tissue and is potentially cytotoxic [27]

Glutathione abundance also increases in plants infected with avirulent pathogens during incompatible interactions, but decreases in plants during compatible interactions 12,13