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One critical factor that must be considered is the potential side effects of mTOR inhibitors

Hacioglu C, Kar F

Shimbo D, et al

Structural basis for Cul3 protein assembly with the BTB-Kelch Family of E3 ubiquitin ligases

Nature 465 , 243247 (2010)

Recent evidence indicates that either activation or inhibition of autophagy can disrupt early neurodevelopmental processes and drive progressive cellular changes in SZ [33]