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Cell Calcium 103 , 102543 (2022)

Furthermore, 4 months of therapy led to an increase in lean mass, without changes in body fat, bone density or other health effects

Science 303 , 836839 (2004)

Mechanisms that inhibit propagation of the DNA damage signal to the apoptotic machinery include loss of damage recognition, overexpression of HER-2/neu, activation of the PI3-K/Akt (also known as PI3-K/PKB) pathway, loss of p53 function, overexpression of antiapoptotic bcl-2, and interference in caspase activation

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Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms