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Preclinical studies with PARP inhibitors in GBM showed encouraging results, such as improved radiosensitivity in cells, effectiveness in sensitizing irinotecan- and temozolomide-resistant tissues, reduced growth of GBM cells, and improved survival in animal models [159]

2013;8:e82659

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Not all NOTCH is created equal: the oncogenic role of NOTCH2 in bladder cancer and its implications for targeted therapy

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