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Innovation 2 , 100140 (2021)

These mechanisms elucidate the pathological underpinnings of ferroptosis across a spectrum of diseases and suggest potential therapeutic targets

While tightly regulated MLCK and ROCK signalling supports normal epithelial transport and barrier modulation, excessive or sustained activation of these pathways contributes to pathological intestinal barrier dysfunction observed in inflammatory and infectious conditions (Xiong et al., 2026)