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In this process, exercise-induced lactate accumulation can trigger the lactate clock, promoting the transition of microglia to a reparative phenotype [47]

Moreover, HIF-1 regulates the transcription of genes responsible for producing proteases that alter or break down the extracellular matrix, thereby promoting the invasion of cancer cells

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Mihalic ZN, Kloimbck T, Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Kindler O, et al

Notably, the anti-inflammatory effects are intensity-dependent, with high-intensity swimming suppressing Th1/Th17 responses more effectively than moderate exercise [300]