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Blood 107 , 19962003 (2006)

Melatonin has strong anti-oxidant capacity that helps prevent or delay the dysfunction of cochlear OHCs [98], as well as the ototoxicity caused by cisplatin [99] and noise exposure-induced hearing loss [100]

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Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)

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