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Although several preclinical studies and clinical trials aimed at reducing oxidative stress using various anti-oxidant molecules have been performed (Rueda Revilla and Martnez-Cu, 2020), none of them has looked at the level of CBS expression and/or activity

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Inhibiting oxalate formation curbs inflammation and fibrosis Considering that AGXT overexpression attenuated hepatic inflammation and fibrosis in MASH, we next sought to determine whether the pharmacological targeting of hepatic oxalate overproduction in mice with established MASH is sufficient to suppress proinflammatory and profibrotic responses

Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Arajo I, Liu ZW, Horvath TL