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Sulfotyrosine-containing peptides may lose their activity due to the desulfation

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Each subunit consists of two integral membrane-spanning segments, a reentrant P-loop that forms the selectivity filter, and cytoplasmic amino- and carboxy-termini (Pegan et al., 2005)both of which are controlled by a combination of stimuli originating from the cytoplasmic and membrane environments (Whorton and MacKinnon, 2011)