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This aggressively disrupts the formation of mitochondrial respiratory supercomplexes, effectively creating a physical bottleneck that chokes off cellular energy production

Biomed Pharmacother 105:491497

The compound did not appear to affect food intake, behavior, or general health status in treated animals

For example, low-dose bortezomib induces autophagy and reduces mutant huntingtin aggregation in HD models

In vitro experiments indicated that incubation with CGA at its IC50 concentration for 96 h resulted in the arrest of L-02 cells in the S phase of the cell cycle and induced apoptosis