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Over the past 50 years, consistent preclinical evidence has shown that methionine restriction therapy (MRT) exerts broad-spectrum antitumor activity against both solid tumors (e.g., colorectal and melanoma) and hematological malignancies (4, 17, 18)

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This suggests DNA damage at telomeres, as these proteins are recruited to sites of DNA damage or dysfunction

Currently, the identity of tethers is being elucidated not just for the ER and mitochondria 174 , but also for peroxisomes: pioneering studies in yeast have used peroxisome inheritance to identify a Pex3p-Inp1p complex that attaches them to the ER 175

Clinical Techniques in Small Animal Practice