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Rheumatology 59(4):820827 Ibrahim AM, Shoman ME, El-Dien RTM, Saber EA, Abdelnaser M, Maher SA, Hayallah AM, El-Rehany MA-A, Abuo-Rahma GE-DA (2025) Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPAR modulator

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Second, given that the activation of GSR and TXNRD1 are involved in ROS elimination, if the LCS3-triggered lethality of VRK2-KO PC cells could be attributed to inhibiting the activity of both GSR and TXNRD1, then the level of ROS generated by LCS3 should have been much higher than those produced by the treatment of the TXNRD1 inhibitor auranofin