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Table 6

Phospholipid peroxidation can be catalyzed by oxidoreductases, including POR and NADH-cytochrome b5 reductase (CYB5R1), which can generate hydrogen peroxide (H 2 O 2 ) through transferring electron and hydrogen atoms from NAD(P)H to oxygen, following which H 2 O 2 produces reactive hydroxyl radicals through Fenton reaction for the peroxidation of membrane PL-PUFA chains, thus vandalizing the integrity of the cellular membrane and initiating ferroptosis [14]

doi: 10.1007/s10545-010-9150-2 106

Sturm, J

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2023A1515030207), China Postdoctoral Science Foundation (No