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Effector functions that are triggered unequally by different nAbs but that are important for protection in vivo, or poor mimicry of in vivo neutralization by the in vitro assay, may be contributory factors

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In a statement, it said the onus was on practitioners to do the right thing and follow good practice, including "only recommending treatments when there is an identified therapeutic need and a reasonable expectation of clinical efficacy and benefit"

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It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys