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10.1073/pnas.2016584118

Less common but serious side effects include pancreatitis, gallbladder issues, and (in rare cases) thyroid tumors in patients with a personal or family history of medullary thyroid cancer or MEN-2

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Related research context BPC-157 is part of the peptide-based healing and tissue repair research class, commonly studied in models involving angiogenesis, extracellular matrix remodeling, and soft-tissue recovery

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The in vivo CL was predicted from the scaled CL int by applying a parallel-tube blood-flow model that incorporates plasma protein binding and blood/plasma ratios (B/P) [16, 17], as described in the equation below: Allometric Scaling The CL and V ss of M8891 in human were estimated based on preclinical in vitro and in vivo PK data obtained in 4 species using allometric scaling approaches corrected for protein binding and CL int (CL-NAS fub , V-SA fub ) [18,19,20,21]