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Monday + Thursday) Total per week: 45 mg Aggressive loading (severe / acute injuries): 5 mg per injection , twice weekly = 10 mg/week Conservative loading (prevention / budget): 2.5 mg per injection , twice weekly = 5 mg/week Duration: 46 weeks Total peptide for standard loading: approximately 4050 mg (standard) or 80 mg (aggressive) TB-500 maintenance phase dosage Standard maintenance dose: 22.5 mg once weekly Reduced maintenance: 2 mg every 2 weeks (for long-term joint support) Duration: 48 weeks after loading

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Demonstrating biological activity whether administered systemically, locally, orally, or intraperitoneally in pre-clinical models and and by the breadth of its cytoprotective, tissue repair, and angiogenic effects across virtually every organ system examined in the research literature