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Differences in iron metabolism appear to underlie this discrepancy, as M-CLL cells presented increased expression of TFRC/CD71 and DMT1, leading to increased intracellular Fe 2+ levels

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In support of this hypothesis, six of these DEGs ( TNXRD1 , SRXN1, GCLM, AKR1B10, OSGIN1, and TRIM16L) are already known to be direct NRF2 transcriptional targets [41,42,43,44,45,46]