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(4) E + S ES (5) ES = E + P Why the substrate S would be bound selectively into the enzymes active site is explained in terms of the well-known lock and key principle (and its updated induced-fit modification) [Kent, 2000]

Assessment and further workup Based on the current understanding of pharmacologically induced ischaemic priapism and improved reporting of aetiologies, we propose an algorithm in Fig

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